TNF and Crohn disease: The lack of effects on their gastrointestinal involvement might be attributed to the resemblance of such a manifestation in BD to Crohn disease for which TOF is known to be ineffective.[21] Moreover, another report investigated 13 patients with severe posterior uveitis including 6 refractory to anti-TNF therapy.[22] They received 30 mg daily doses of prednisone and 5 mg TOF 2 times a day, resulting in a rapid and sustained improvement in visual acuity.