In contrast, integrins, cytoskeleton regulators, and anti‐microbial genes along with IRF2BP2, CD83, BTG1, and WNT10B with anti‐proliferative and anti‐inflammatory activity were not a function of high parasitemia (Fig 6H), raising the possibility that low parasitemia asymptomatic P. falciparum infections activate a blood transcriptional profile that drives immunosuppressive processes. This evidence concerns the gene IRF2BP2 and parasitic infectious disease.