Genes in cluster 4 (Fig 6C), underrepresented in symptomatic malaria and upregulated by asymptomatic infection, included several genes encoding protein products mediating negative regulation of immune processes, such as the anti‐proliferative molecules BTG1 and NDRG2, as well as the checkpoint receptor CD83 (Fig 6D and E). Here, NDRG2 is linked to infection.