BUB1 and malaria: Gene set enrichment using gene ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and Ingenuity Pathway Analysis (IPA) showed significant upregulation of terms involved in cell proliferation in symptomatic malaria (Fig 5B–E), including genes encoding cyclins such as CCNB1 and CCNB2, MKI67, replication factors such as CDT1 as well as mitotic checkpoint kinases like BUB1 (Fig 5B).