tSNE and FlowSom analysis of gated CTLA‐4+CD4+ T cells revealed clear differences in the composition of the CTLA‐4+ pool expanding during peak parasitemia and asymptomatic recrudescence, with high frequencies and absolute numbers of CD44+CCR7−CD62Llow cells consistent with an effector memory phenotype, coinciding with the onset of recrudescent infection (Fig 9L–Q). Here, CD44 is linked to parasitic infectious disease.