Furthermore, administration of anti‐CTLA‐4 blocking antibodies to P. chabaudi chabaudi‐infected mice from day 13 p.i resulted in a 10‐fold reduction in recrudescent parasitemia levels compared to controls (Fig 9R), providing proof of concept for CTLA‐4 as an immunoregulatory pathway contributing to the development of persistent asymptomatic parasitemia after malaria infection. Here, CTLA4 is linked to parasitic infectious disease.