It had been found that knockdown of FGD5-AS1 in NSCLC cells increased the ratio of CD8+ T cells and reduced the apoptosis of CD8+ T cells, which were completely reversed by blocking the PD1/PD-L1 interaction using the anti-PD-1 or anti-PD-L1 peptides [96]. This evidence concerns the gene CD274 and non-small cell lung carcinoma.