Importantly, BRAF V600E was detected in 3 cases with otherwise nonspecific histopathological diagnoses including “Infiltrating astrocytoma,” “Astrocytoma, NOS,” and “Low grade astrocytoma, NOS,” thus providing not only therapeutic information but crucial diagnostic information in revealing a putative oncogenic driver, thereby making it much less likely that other diagnostically relevant drivers were being missed (eg, an H3 alteration in the case of the infiltrating astrocytoma). This evidence concerns the gene BRAF and astrocytoma (excluding glioblastoma).