Methylation profiling offered additional class information or refined diagnostic precision in 5 additional non-medulloblastoma cases (9% of cases in this cohort) including a “CNS embryonal tumor, NOS” that classified most closely to a FOXR2-altered tumor (calibrated score of 0.717; patient P26); and a patient whose tumor demonstrated histological features of an infiltrating astrocytoma and was shown to have a methylation profile most closely resembling that of an adult-type IDH-wildtype glioblastoma (calibrated score of 0.88; patient P4). This evidence concerns the gene FOXR2 and glioblastoma.