First links between ArgMet and neurodegenerative diseases have been suggested, as hypomethylated RNA-binding proteins FUS and poly-GR dipeptide repeats were found to be enriched in patients with frontotemporal dementia and amyotrophic lateral sclerosis, respectively (Dormann et al., 2012; Gittings et al., 2020; Suarez-Calvet et al., 2016). Here, FUS is linked to amyotrophic lateral sclerosis.