Although the genetic features of PCa remain unclear to date, the racial differences associated with the most frequent genetic alterations of the transmembrane protease, serine 2 (TMPRSS2)‐v‐ets avian erythroblastosis virus E26 oncogene homolog (ERG) gene fusion and phosphatase and tensin homolog (PTEN) inactivation have been reported. The gene discussed is TMPRSS2; the disease is posterior cortical atrophy.