identified a new subset of tumor‐infiltrating CD4+CD69+ Tregs (Figure 1) that expressed neither CD25 nor FOXP3, but highly expressed membrane‐bound TGF‐β1 (mTGF‐β1), programmed cell death protein 1 (PD‐1, CD279), and CTLA‐4.144. This evidence concerns the gene PDCD1 and neoplasm.