have reported that blockade of TNFR2 signaling with an antibody could markedly reduce the tumor‐infiltrating TNFR2+ Tregs (Figure 1) in CRCs, whereas the number of tumor‐infiltrating interferon‐γ‐positive (IFN‐γ+)CD8+ cytotoxic T lymphocytes were significant increased.88 This evidence concerns the gene IFNG and neoplasm.