When serum IL‐2 levels were reduced in patients with SLE, the proportion of CD4+CXCR5+FOXP3–PD‐1high Tfhs was increased, whereas the proportion of CD4+CXCR5+CD45RA–FOXP3high Tfrs was decreased.245. The gene discussed is CD4; the disease is systemic lupus erythematosus.