Moreover, uTregs also exhibited a special phenotype similar to tumor‐infiltrating Tregs, which highly expressed IL1R2, LAYN, CD80, TNFRSF4, etc. Although these findings deepen our understanding of Tregs at the maternal‐fetal interface and show great clinical application potential, the clinical application of these phenotypes still needs more trials to verify. This evidence concerns the gene TNFRSF4 and neoplasm.