While protein expression of METTL3, METTL4, METTL14, and KIAA1429 was decreased in ccRCC, an increase of expression was observed in METTL4 and WTAP in pRCC, and METTL3 and METTL14, that did not show significance, yet showed a similar trend, see Figure 5. The gene discussed is METTL4; the disease is nonpapillary renal cell carcinoma.