MAPT and early-onset autosomal dominant Alzheimer disease: Yet, in Alzheimer’s disease (AD) brains, where diseased Tau disrupts the microtubule cytoskeleton, Tak1 and the ortholog of Drosophila IK2 (Table 1), Tank binding kinase 1 (Tbk1), are seen phosphorylated and colocalise with diseased Tau.