We have recently identified recurrent somatic mutations within the liver of patients with NAFLD and ARLD14 Recurrent non‐synonymous mutations were seen in six coding genes: ACVR2A, ALB, CIDEB, FOXO1, GPAM, TNRC6B, plus the long non‐coding (lnc)RNA NEAT1. The gene discussed is TNRC6B; the disease is metabolic dysfunction-associated steatotic liver disease.