Therefore, we hypothesized that variants located in the ABCC8 and TRPM4 genes may lead to an increased risk to develop cerebral edema and thus infants susceptible to SIDS and investigated 185 SIDS cases and 339 controls for 24 polymorphisms in candidate genes involved in the SUR1-TRPM4 non-selective cation channel relevant to the development of cerebral edema. Here, TRPM4 is linked to brain edema.