DNER and obesity due to melanocortin 4 receptor deficiency: In particular, three biomarkers of subclinical inflammation, including two chemokines (C-C motif chemokine ligand 7 [CCL7], C-X-C motif chemokine ligand 10 [CXCL10]) and the soluble form of the transmembrane receptor (Delta/Notch-like epidermal growth factor-related receptor [DNER]) partially mediate the association between obesity and DSPN [4].