HK2 and neoplasm: To further verify our hypothesis, we overexpressed HK2 in shCASC7-transfected cells and found that glucose secretion was significantly reduced (Fig. 4D), lactic acid was obviously increased (Fig. 4E), and the extracellular acidification rate was significantly increased (Fig. 4F), indicating that lncRNA CASC7 affects the process of tumour glycolysis by regulating HK2.