Providing robust IL-2 signals to Lm-A8- and Lm-T4-primed Il2ramut/mut OT-I cells, using IL-2/anti-IL-2 monoclonal Ab (mAb) treatment for 6 days during primary infection, showed significant rescue of their ability to expand compared to control isotype Ab-treated counterparts during secondary antigen encounter after Lm-N4 challenge infection (Fig. 2c). Here, IL2 is linked to infection.