Ad-VP35 infection also resulted in a prolonged prothrombin time (PT), a reduced fibrinogen (FIB) level, and a subsequently prolonged tail bleeding time in the WT but not Akip1−/− mice exposed to Ad-VP35, regardless of challenge with or without LPS, a well-known activator of coagulation34, changes that were nearly completely rescued by the CREB1 inhibitor 666-15 (Fig. 7e and Supplementary Fig. 9h). This evidence concerns the gene CREB1 and infection.