METTL3 and glioma: To verify the role of METTL3 in the regulation of glioma cells by circDLC1, we transfected three METTL3 siRNAs (si-METTL3) into LN229 cells respectively (p < 0.05, Fig. 4A, B) and selected si-METTL3#2 with the best transfection efficiency for subsequent experiments.