To evaluate whether loss of perivascular AQP4 localization increases Aβ levels, we evaluated the effect of Snta1 gene deletion within the Tg2576 amyloidosis line, comparing soluble and insoluble Aβ levels by ELISA in Tg2576:Snta1−/− mice and Tg2576:Snta1+/+ littermate controls at 6 months of age (Fig. 6C). Here, AQP4 is linked to amyloidosis.