AGT and aneurysm: Under pathological conditions, the atherosclerotic lesions at the aortic arch appear earlier and more severe than at other positions.6 Abdominal aortic aneurysm is one of the most severe vascular diseases with a high incidence and mortality but low control rate.7 The most typical and generally accepted animal model of AAA is the AngII-induced model, which mimics most human AAA features.8 However, more than 95% of this model with AngII infusion throughout the body can only cause aneurysms in the abdominal aorta (Supplementary Fig. S2a).