EGF and neoplasm: In a study by Camaj et al., fibulin-3 was found to compete with EGF in binding EGFR and cause EGFR autophosphorylation in pancreatic adenocarcinoma with the subsequent signal transduction including Akt and MAPK phosphorylation, which may contribute to the tumor growth in pancreatic carcinomas with fibulin-3 overexpression.