RB1 and hepatocellular carcinoma: For instance, the Retinoblastoma (Rb)-1 tumor suppressor gene is the target of miR-212 in PDAC (increased miR-212 suppresses Rb1 that promotes cell growth), but Rb binding protein-2 (RBP2) is the target in gastric carcinoma and HCC (decreased miR-212 upregulates RBP2 which promotes cell growth) [4].