Next, a protein–protein interaction (PPI) network was construct and Gene Set Enrichment Analysis (GSEA) was performed to predict the potential functions of NOP14. Finally, we assessed the correlations between the NOP14 expression level and immune infiltration as well as immune molecules, to unravel the role of NOP14 in the prognosis of CRC patients. Here, NOP14 is linked to colorectal carcinoma.