AHR and melanoma: For instance, Zhong et al. observed increased expression of ARNT after CoCl2 incubation in PC-3 cells [41]; Mandl et al. showed that ARNT is up-regulated in an HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions [40]; Kim et al. concluded that AhR and ARNT expression was dose- and time-dependently up-regulated in PCB-, BaP-, and TBT-exposed intertidal copepod Tigriopus japonicas [42].