TMBIM4 and heart failure: Sig-1 R KO mice showed mitochondrial dysfunction and abnormal cardiac remodeling and eventually systolic dysfunction, stressing the fundamental need for maintaining systolic function.[20] Furthermore, fluvoxamine remarkably rescued heart failure and cardiac dysfunction in transverse aortic constriction animal models by activating S1R.[14], 15 S1R was also documented to be highly expressed in the right ventricle.[14] However, to the best of our knowledge, little is known about the role of S1R in the RV, especially in RV dysfunction.