Studies have shown that cancer-associated fibroblasts in primary tumours enhance tumour cell invasion by secreting cancer-associated fibroblast chemokine (C-X-C motif) ligand 1 (CXCL1) and interacting with C-X-C motif chemokine receptor 2 (CXCR2) in tumour cells [34]. This evidence concerns the gene CXCL1 and cancer.