In CESC, KIRP, LUAD and PAAD, the high expression of RIPK2 had a poor prognosis, but in CESC, KIRP, LUAD and PAAD, the expression of RIPK2 was positively correlated with that of GZMB, NKG7 and PRF1. The gene discussed is RIPK2; the disease is pancreatic adenocarcinoma.