In CESC, KIRP, LUAD and PAAD, the high expression of RIPK2 had a poor prognosis, but in CESC, KIRP, LUAD and PAAD, the expression of RIPK2 was positively correlated with that of GZMB, NKG7 and PRF1. This evidence concerns the gene PRF1 and pancreatic adenocarcinoma.