Moreover, we evaluated the GSE performance of the same set of top, middle, and bottom ranked EnTDefs for two dataset pairs: genome-wide DNA methylation (WGBS) and RNA-seq data for the same tumor samples comparing two subtypes of HPV-associated head and neck cancer, and ATAC-seq and RNA-seq datasets studying overexpression of the transcription factor Sox17 in the same cells (see “14”). Here, SOX17 is linked to head and neck cancer.