In RA, various inflammatory cells are activated that secrete pro-inflammatory cytokines, such as TNF-α and IL-1β, triggering a long-lasting inflammatory cascade [30] Additionally, overexpressed vascular growth factor and excessive proliferation of synovial fibroblasts lead to joint expansion and deformation of cells [31] Therefore, anti-inflammation and anti-proliferation are necessary for the treatment of RA. The gene discussed is TNF; the disease is rheumatoid arthritis.