In the present study focusing on the most vulnerable group to ventricular arrhythmia [22], the association between hyperuricemia and the prevalence of VT/VF remained statistically significant after adjusting for potential confounding factors including age, sex, history of hypertension, eGFR, hsCRP, serum natrium, peak troponin I, BNP, plasma fasting glucose and VT/VF in PPCI, suggesting hyperuricemia is not merely an innocent bystander but may be implicated in the development of VT/VF in STEMI patients. This evidence concerns the gene NPPB and Ventricular arrhythmia.