Furthermore, the NOTCH3–PAH link has recently been corroborated by the identification of NOTCH3 missense mutations (NOTCH3G840E and NOTCH3T900P) in patients with childhood PAH [112] and a NOTCH3 single nucleotide polymorphism (SNP) segregating with childhood PAH [113]. The gene discussed is NOTCH3; the disease is pulmonary arterial hypertension.