The discovery that Notch3 regulates PDGFRB links two important signalling pathways in VSMC differentiation and a Notch–PDGF signalling axis may in fact not be restricted only to mural cells, as it was recently observed that a NOTCH3 gain-of-function (NOTCH3L1519P) elevated PDGFRB expression in infantile myofibromatosis, a non-metastatic cancer formed in bone, skin and muscle [70]. Here, PDGFRB is linked to infantile myofibromatosis.