CD274 and neoplasm: Targeting the PD-1:PD-L1 pathway or CTLA-4 to enhance anti-tumor T cell activity, termed immune checkpoint blockade (ICB) therapy, results in striking clinical responses in some tumors including melanoma, renal cell carcinoma, and non-small cell lung cancer (Brahmer et al., 2012; Hodi et al., 2010; Topalian et al., 2012).