The analysis of chemokine receptors (Fig. S4 E) highlighted a complete switch in expression from molecules mediating recruitment (Ccr2, Ccr3, Ccr4, Ccr5, Cxcr3, Cxcr4, Cxcr5; Harlin et al., 2009; Nagarsheth et al., 2017) to receptors that potentially contribute to retention within the tumor (Ccr8, Ccr10; Facciabene et al., 2011; Plitas et al., 2016). This evidence concerns the gene CCR4 and neoplasm.