Since Kaede Red+ Tregs in the dLN and spleen expressed significantly less CD25 and CD39 than LAG-3+ Tregs in the tumor, our data was consistent with the egress of LAG-3− Tregs, rather than simply the downregulation of LAG-3 by Tregs upon or after egress (Fig. 3 I). The gene discussed is LAG3; the disease is neoplasm.