GZMK and cancer: There were further striking changes in the expression of cytotoxic molecules (e.g., switch from Gzma, Gzmk to Gzmc-f; Fig. 4 H), and chemokines (e.g., upregulation Ccl1, Ccl2, Ccl7, and Ccl27) associated with worse cancer prognosis (Eckstein et al., 2020; Hwang et al., 2012; Kuehnemuth et al., 2018; Simonetti et al., 2006; Fig. S4 D).