Targeting the PD-1:PD-L1 pathway not only drives the reinvigoration of exhausted T cells (Blackburn et al., 2008; Freeman et al., 2006) but also enhances T cell priming in the dLN to then drive superior T cell responses within the tumor (Dammeijer et al., 2020). The gene discussed is PDCD1; the disease is neoplasm.