As previously reported, obesity resulted in a significant decrease in the percentage of circulating CD4+CD25+Foxp3+ regulatory T cells (Fig 1D) but a decreased proportion of peripheral blood monocytes (F4/80+ CD11b+ and CD11b+) (Fig 1E) compared to lean controls [39, 40]. The gene discussed is ITGAM; the disease is obesity due to melanocortin 4 receptor deficiency.