CCR7 and obesity due to melanocortin 4 receptor deficiency: In this context, obesity was has been shown to affect Treg mobilization by altering their phenotypic features, such as homing patterns of VAT peripheral Tregs as seen by the enhanced expression of CCR7 in splenic Tregs and their reduced VAT infiltration [39], which may establish an inflammatory state, implicated in the intratumoral infiltration in HFD-fed animals, therefore promoting tumor growth.