RHO and retinal degeneration: To determine whether the nonretinoid chaperones rescue RHO proteostasis and ameliorates retinal degeneration in the RhoP23H/+ retinae (a model of adRP), we treated mouse RhoP23H/+ and WT retinal explants with multiple doses of YC-001, F5257-0462, or DMSO for 9 DIV before collecting the tissue for analysis (Figure 5 and Supplemental Figures 7 and 8).