EBF1 and viral infectious disease: Since increased EBF1 expression was previously shown to be highly inversely correlated with enhanced lytic viral infection in a series of T1 LCLs [46], and EBF1 was recently shown to inhibit the activity of the BRLF1 IE promoter in epithelial cells [47], we hypothesized that decreased expression of EBF1 in T2 EBV-infected LCLs also contributes to their lytic phenotype.