Conversely, over-expression of IRF4 in the EBV-positive Akata Burkitt lymphoma line (which normally expresses no detectable IRF4 protein) decreased constitutive (and BCR-activated) expression of the BZLF1, BRLF1 and BMRF1 lytic proteins (Fig 9B). This evidence concerns the gene IRF4 and Burkitt lymphoma.