IRF4 and Burkitt lymphoma: We show here that IRF4 knock-down in T1 LCLs infected with Akata EBV promotes lytic EBV reactivation (Fig 9A), while over-expression of IRF4 in the Akata Burkitt lymphoma cell line (which do not normally express IRF4) inhibits lytic EBV reactivation (Fig 9B).