Analyses of NCBI’s Gene Expression Omnibus (GEO) database for gene expression (GSE89408) revealed that UHRF1 mRNA was also significantly upregulated in synovium from patients with RA compared with healthy individuals and patients with osteoarthritis (OA), which had similar UHRF1 mRNA levels (Figure 1G). This evidence concerns the gene UHRF1 and osteoarthritis.