We observed a significant loss of keratins preferentially expressed in the normal differentiated cells, including KRT16, KRT17, KRT80, KRT78, KRT23, and KRT19 (compare average expression heatmap [Figure 5B] to transcriptional change [Figure 5C] in the differentiated subpopulation in active EoE). The gene discussed is KRT16; the disease is eosinophilic esophagitis.