Notably, expression of CAPN14, the protein product of the main EoE susceptibility locus (2p23), and expression of CCL26, the critical driver of the eosinophilic infiltration in EoE, paralleled each other, suggesting common regulation in response to IL-13; they were significantly upregulated throughout the EEU. The gene discussed is CAPN14; the disease is eosinophilic esophagitis.