Genes enriched in CM2 included the L-type calcium channel Cacna1c, associated with sustained AF (32); Ablim1, which encodes an actin binding protein associated with left-right asymmetry and is expressed in the developing LA (33); Ivnsabp1, encoding an actin binding protein that functions in cytoskeleton stabilization (34); Fhl2, encoding a LIM-containing protein associated with adrenergic stress signaling (35); and Tacc2, a centrosomal protein (36). This evidence concerns the gene CACNA1C and atrial fibrillation.