In addition, in Pitx2 mutants, the CM1 populations of the PV and LA both showed a gain in Bmp10 and Etv1 and a loss in Stat3, Nr4a3, Pdlim5, and Slc24a2, among other genes with known roles in AF predisposition (Supplemental Table 6). Here, PITX2 is linked to atrial fibrillation.