NDUFV2 and neoplasm: This paper selected three NDUFV2 interference plasmids and one negative control empty plasmid to transiently transfect MCF-7/ADR and SMMC-7721/ADR cells with LipofectamineTM 2000, to screen out the interfering plasmid with the best inhibitory effect on the expression of the NDUFV2 gene and proteins, and verify the inhibitory effect of NDUFV2 gene silencing on the growth of two drug-resistant tumor cell lines by MTT assay.