Surprisingly, a group of AID C‐terminal deletion (AIDΔC) alleles, which lack the C‐terminal NES, were reported in immunodeficient Hyper‐IgM syndrome type 2 (HIGM2) patients, including R190X, V186X, etc. (Durandy et al, 2007). The gene discussed is AICDA; the disease is hyper-IgM syndrome type 2.