Here, we focused on 3 of these factors: the core PCP/Wnt factor Vang, which proteomic data indicate is reduced by a factor of 5 in Nab2ex3 brains (Corgiat et al. 2021), the accessory factor Appl (Amyloid precursor protein-like), which is a proposed PCP/Wnt coreceptor and has established links to neurological disease (Singh and Mlodzik 2012; Soldano et al. 2013; Liu et al. 2021), and the PCP/Wnt cytoplasmic adaptor Dsh, which also genetically interacts with Nab2 in the wing to control hair polarity (Lee et al. 2020). Here, APPL1 is linked to nervous system disorder.