VANGL2 and Cognitive impairment: Given that loss of the Nab2 ortholog in mice, Zc3h14, also alters levels of the Vangl2 PCP protein in the adult hippocampus, and that mutations in PCP genes including Vangl2 are linked to intellectual disabilities, severe neural tube closure defects, and microencephaly in humans (e.g. Wang et al. 2019) dysregulation of the PCP signaling in neurons is one potential mechanism to explain axonal and dendritic phenotypes in Zc3h14 mutant mice (Jones et al. 2021) and cognitive defects in human patients lacking ZC3H14 (Pak et al. 2011).