APOE and Alzheimer disease: In particular, we found a significant correlation between the insoluble α-SYN and insoluble Aβ40, Aβ42, and APOE which were not observed in AD brains without LB (Table 4; Supplementary Fig. 1a–d, online resource), suggesting that the presence of LB may intensify associations between α-SYN aggregates and AD-related pathologies in this brain region.