APOE and Alzheimer disease: To explore the effects of APOE4 on α-SYN, we further subdivided the cohort into APOE4 non-carriers (APOE4−, including APOE2/3 and APOE3/3, N = 80 in AD group and N = 78 in AD + LB group) and APOE4 carriers (APOE4+, including APOE2/4, APOE3/4 and APOE4/4, N = 134 in AD group and N = 177 in AD + LB group) (Table 1).