Interestingly, a genome-wide association study (GWAS) of LBD revealed the top hit to be APOE4 (OR 2.46; p = 3.31 × 10–64) [21], although the effect is less than that seen in AD (OR 3.32; p = 1.2 × 10–881) [34]. This evidence concerns the gene APOE and Alzheimer disease.