In AD, about 60% of soluble tau proteins were in the size range of 73 and 96 kDa (fractions #40 and #41, Fig. 4a–c); whereas the peaks of tau proteins in control brains were distributed from 96 to 202 kDa (fractions #37 to #40, Fig. 4d–e). Here, MAPT is linked to Alzheimer disease.