APOE and Alzheimer disease: In the AD brains without LB, we observed a significant (p < 0.0042 considered significant after multiple testing corrections) association between the levels of α-SYN in TBS with Aβ42 in TBSX fractions, α-SYN in TBSX with Tau in TBSX and FA fractions, α-SYN in TBSX with Aβ42 in all three fractions, as well as α-SYN in FA with tau in FA fractions, after adjusting for age at death, sex, CAA score, number of APOE4 alleles, Braak stage, and Thal phase (Table 3).