To evaluate α-SYN aggregates and assess the potential effects of APOE4 in the presence of Aβ, we used autopsy-confirmed AD cases (N = 469) (Supplementary Table 1, online resource) [35] with 214 (46%) cases having no α-SYN pathology (AD) and 255 cases (54%) having α-SYN pathology (AD + LB). The gene discussed is APOE; the disease is Alzheimer disease.