GZMB and neoplasm: In situ IHC analysis revealed increased tumor-infiltrating CD8+ T cells and granzyme B+ elements in support of locally induced cytotoxic response, which was more robust in NPMc+ NET/DC than NPMc-derived MHC-I peptides/DC vaccinated mice (Figure 4D–F and Figure 4—source data 4 and Figure 4—source data 5).