NPM1 and acute myeloid leukemia: We have recently described extracellular traps enrichment in bone marrow (BM) biopsies from NPM1 mutant acute myeloid leukemia (AML) patients and, using an ad hoc transgenic mouse, we showed that NPM cytoplasmic compartmentalization allows mutant NPM (NPMc+) to be relocalized onto the NET threads, exerting alarmin functions (Tripodo et al., 2017).