FTDP tauopathy model mice that overexpressed with mutant tau are widely used to examine tau toxicities on synaptic plasticity (Polydoro et al., 2014; Sydow et al., 2011; Yoshiyama et al., 2007), memory formation (Sydow et al., 2011; Santacruz et al., 2005), as well as on synaptic vesicle (SV) transport (McInnes et al., 2018; Zhou et al., 2017). This evidence concerns the gene MAPT and tauopathy.