MAPT and Alzheimer disease: As AD models, the effects of WT tau overexpression have been examined in culture cells (Ebneth et al., 1998; Shahpasand et al., 2012; Stamer et al., 2002; Thies and Mandelkow, 2007) or in Drosophila (Mudher et al., 2004), where impaired axonal transports associated with increased MT density were found.