We next examined intestinal alkaline phosphatase (IAP) activity since IAP activity plays a significant role in maintaining intestinal homeostasis and protection with reduced activity associated with worsened mucosal inflammation and metabolic syndrome.34 The MD and MF diets show increased IAP activity than the CO and OO diets (Figure 5i), suggesting that saturated fat plays a key role in IAP function. The gene discussed is ALPI; the disease is metabolic syndrome.