IL5 and Menkes disease: Eosinophils have been found in the inflamed tissue of colitis patients, leading to increase diarrhea, inflammation, and tissue destruction promoted by the action of IL-5.25,26 We saw reduced eosinophils and serum IL-5 (Table 2) in the MD in comparison to the mice fed CO, further demonstrating the protective immunomodulatory effects of a fat blend (MD), favoring a milder colitis phenotype.