IFNLR1 and Zika virus infectious disease: In a mouse model of congenital ZIKV infection, IFN-λ restricted transplacental transmission, as fetuses from Ifnlr1−/− pregnancies (Ifnlr1−/− × Ifnlr1−/−) sustained higher fetal and placental viral loads than those from wild-type (WT) pregnancies (9).