Additionally, exosomes derived from CD133+/CD44+ colorectal cancer cells after being transfected with sh-LINC01315 down-regulated BCL-2, MMP-9, and Vimentin, whereas up-regulated Bax, cleaved caspase-3, and E-cadherin in colorectal cancer cells (P < 0.05). The gene discussed is CASP3; the disease is colorectal cancer.