As illustrated in Figure 6(a–e), exosomes derived from CD133+/CD44+ colorectal cancer cells up-regulated BCL-2, MMP-9 and Vimentin, while down-regulating Bax, cleaved caspase-3 and E-cadherin in colorectal cancer cells, as compared with those in the control group (P < 0.01). This evidence concerns the gene PROM1 and colorectal cancer.