Then, we discovered that the expressions of tumor-initiating cell markers encompassing Oct-4, Prominin and SOX2 were all reduced by sh-LINC01315#1 in CD133+/CD44+ SW480 cells and CD133+/CD44+ HCT116 cells (P < 0.001, Figure 1(e–g)). The gene discussed is CD44; the disease is neoplasm.