Factors such as age and hormone levels (estrogen and testosterone) that affect visceral adiposity41 in addition to sex differences that co‐occur with obesity (HDL cholesterol, plasma insulin, glucose, and TG41) may correlate with the accumulation of gender‐specific ceramides and may prove beneficial when profiling diabetic risk. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.