HLA-DRB5 and infection: Genes affecting cell developmental trajectory were divided into two clusters: State 1, which mainly from NHIC, consisted of genes highly expressed the genes related to inflammation and chemokines, such as CCL2, CXCL8, CXCL3, and antigen presentation (HLA‐DRB5) and NRP2; State 3, which includes IFITM2, TXNIP, PTPRC, and JUNB, was enriched in the infection response (Figure 3D).