NFKB1 and neoplasm: Production of tumor-promoting cytokines by inflammatory cells that activate transcription factors, such as nuclear factor-κB (NF-κB), signal transducer and activator of transcription 3 (STAT3) and activator protein 1 (AP-1), in pre-malignant cells to affect genes that induce cell proliferation and survival, is a major carcinogenesis mechanism [7].