demonstrated that LCN2 promotes pancreatic ductal adenocarcinoma (PDAC) by modulating the secretion of proinflammatory cytokines in human pancreatic cancer stellate cells, the first suggestion of a possible mechanism through which LCN2 contributes to the development of PDAC in the tumor microenvironment [39]. The gene discussed is LCN2; the disease is familial pancreatic carcinoma.