KMT2A and Hyperglycemia: Interestingly, the protein levels of H3K4 methyltransferase, Mll1 were up-regulated due to hyperglycemia in embryo brains and treatment with OGT inhibitor restored Mll1 to normal levels, suggesting that this increased Mll1 could have resulted in H3K4me3 enrichment on the affected gene promoters.