As shown for SC-fed IL-6Ra KD mice, HF-fed IL-6Ra KD mice that underwent a glucose-stimulated insulin secretion test at week 19 of diet also displayed impaired glucose clearance (Figure 6E, effect of time p < 0.01, effect of genotype p < 0.05 genotype x time p < 0.01) as shown by an increased AUC (Figure 6F, p < 0.01). Here, INS is linked to hydrops fetalis.