In patients suffering tubular bone fractures in addition to TBI (n = 21, all GCS 14-15), mean prehospital and in-hospital S100B concentrations were 0.73 μg/l (95%CI 0.47; 1.14) and 0.39 μg/l (95%CI 0.26; 0.58) respectively. The gene discussed is S100B; the disease is bone fracture.